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KMID : 0367419940370020185
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Journal of Korean Pediatric Society
1994 Volume.37 No. 2 p.185 ~ p.192
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Pharmacokinetics of Gentamicin and Amikacin in Korean Children with Normal Renal Function
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박진영
권경배/김미란/이환종/김진규/신완균/박경호/정혜림
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Abstract
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We analysed retrospectively pharmacokinetic parameters of gentamicin and amikacin in 44 and 58 Korean pediatric patients, respectively, with normal renal function. Pharmacokinetic parameters were calculated from two concentrations in serum by
method of
Sawchuck. There was wide individual variation in peak serum concentrations of gentamicin and amikacin, Administration of the usually recommended doses yielded subtherapeutic concentrations in 47% and 82%, respectevely, of patients in the peak
concentrations of gentamicin and amikacin. The volumes of distribution of gentamicin and amikacin in children of over 1 year of age were 0.37± 0.13L/kg and 0.41± 0.13L/kg which are greater than those reported from the western countries.
We conclude that the wide individual variation and high frequency of subtherapeutic levels in the peak concentrations of gentamicin and amikacin obtained by usually recommended dosage as well as the narrow safety margin of these drugs necessitate
monitoring of serum concentration and adjustment of individual dosage regimen early in the course of treatment with aminoglycosides.
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